The patent abstract shows that the present invention relates to the field of brake disc processing and discloses a brake disc positioning and clamping mechanism, comprising a base plate. The rear side of the top surface of the base plate is provided with an adjusting component, and the left and right parts of the adjusting component are both provided with fixed components. The right side of the top surface of the base plate is provided with a power component, and the left part of the top surface of the base plate is fixedly connected with an auxiliary plate. Two cleaning brushes are jointly provided between the power component and the auxiliary plate, and the adjusting component comprises an installation plate. The installation plate is fixedly connected with the base plate, and the right side of the installation plate is fixedly connected with a first motor. The upper part of the front side of the installation plate is provided with a sliding groove. In the present invention, by setting the mutual cooperation between the adjusting component and the fixed component, the device can be adjusted more conveniently and quickly according to the size of the brake disc. By setting the connecting block, brake discs of different thicknesses can be fixed, making the use of the device more convenient.